Amongst Internet users who reported searching for online health-related information, getting better informed on one’s general health was the most commonly cited reason (53.6% in Europe and 71.0% in the US). This was followed by seeking a second opinion on a medical diagnosis (49.3% in Europe and 57.7% in the US). Considerably fewer cited supporting their role as carer of an ill or disabled person as a reason (24.8% in Europe and 42.6% in the US). Seeking a second opinion online has particular significance for doctor-patient relationships and its prevalence varied widely across the EU Member States.